The Drug Enforcement Administration DEA sets limits on who can make, possess, and use medications that are controlled substances.
However, Cymbalta could cause withdrawal symptoms if you stop taking the drug suddenly. Addiction is different from dependence. Over time, someone with addiction needs more and more of a drug to feel its effects. This is because the drug affects your central nervous system CNS. If you have questions or concerns about your risk for dependence with Cymbalta, talk with your doctor.
Cymbalta is approved to treat mood disorders, such as depression and anxiety. Because it affects your mood, some people report feeling calm or as if their mood is boosted while taking the drug. If you have questions about how Cymbalta may affect you, talk with your doctor or pharmacist. This was one of the more common side effects of the drug in clinical studies. In the studies:. If you have questions about side effects from Cymbalta, talk with your doctor or pharmacist. You may wonder how Cymbalta compares with other medications that are prescribed for similar uses.
Here we look at how Cymbalta and Lexapro are alike and different. Lexapro contains the active drug escitalopram. Lexapro belongs to a class of medications called selective serotonin reuptake inhibitors SSRIs. Both types of drugs are commonly used as antidepressants.
Cymbalta comes as capsule that you take by mouth. Cymbalta and Lexapro have some similar side effects and others that vary. Below are examples of these side effects. This list contains 10 of the most common mild side effects that can occur with both Cymbalta and Lexapro when taken individually :.
These lists contain examples of serious side effects that can occur with Cymbalta, with Lexapro, or with both drugs when taken individually. The use of Cymbalta and Lexapro in treating depression in adults has been compared in a meta-analysis. A meta-analysis is a type of study that looks at the results of numerous clinical studies to see if there are any consistent results across the studies.
In this meta-analysis , researchers looked at 16 different clinical studies that compared Cymbalta to other antidepressants, including three studies that compared Cymbalta with Lexapro. The researchers found the two drugs to be similarly effective for treating depression.
Cymbalta and Lexapro have also been compared in a meta-analysis for treating anxiety in adults. The researchers looked at 41 clinical studies involving a total of 11 antidepressants, including Cymbalta and Lexapro. They found Cymbalta and Lexapro to be similarly effective for treating anxiety. According to estimates on GoodRx. Lexapro is available as a generic drug called escitalopram. Cymbalta and Effexor XR are prescribed for similar uses.
Here we look at how these drugs are alike and different. Effexor XR contains the active drug venlafaxine ER. Duloxetine and venlafaxine ER both belong to a class of medications known as serotonin-norepinephrine reuptake inhibitors SNRIs.
This medication class is commonly used as antidepressants. Cymbalta and Effexor have some similar side effects and others that differ. This list contains 10 of the most common mild side effects that can occur with both Cymbalta and Effexor XR when taken individually :.
These lists contain examples of serious side effects that can occur with Cymbalta, with Effexor XR, or with both drugs when taken individually. The use of Cymbalta and Effexor XR in treating depression in adults has been compared in a meta-analysis. In this meta-analysis , researchers looked at 16 clinical studies comparing Cymbalta with other antidepressants , including three studies that compared Cymbalta with Effexor XR.
A clinical study directly compared Cymbalta and Effexor XR for treating anxiety in adults. In this study, the researchers randomly assigned people to take either Cymbalta, Effexor XR, or a placebo a treatment with no active drug once a day for 10 weeks. At the end of the study, the researchers found that people who took Cymbalta or Effexor XR had improved HAM-A scores compared with those who took a placebo.
They found Cymbalta and Effexor XR to be similarly effective for treating anxiety. Effexor XR is available as a generic drug called venlafaxine ER. Other drugs are available that can treat your condition.
Some may be a better fit for you than others. They can tell you about other medications that may work well for you. Note: Some of the drugs listed here are used off-label to treat these specific conditions. Examples of other drugs that may be used to treat depression include:. Examples of other drugs that may be used to treat anxiety include:.
Examples of other drugs that may be used to treat diabetic neuropathy diabetic nerve pain include:. Examples of other drugs that may be used to treat fibromyalgia include:. Examples of other drugs that may be used to treat chronic musculoskeletal pain pain in the bones, muscles, ligaments, nerves, and tendons include:.
On its own, Cymbalta has caused liver damage and liver failure. In rare cases, this liver damage was fatal. Therefore, drinking heavily during your Cymbalta treatment could raise your risk for liver damage even more. If you drink alcohol, talk with your doctor before you start taking Cymbalta.
Depending on the amount of alcohol you consume, they may decide to have you try a different medication for your condition. Cymbalta belongs to a drug class called serotonin-norepinephrine reuptake inhibitors SNRIs. Cymbalta begins working as soon as you take your dose.
It takes about 3 days for levels of the drug to become stable in your body. For example, in clinical trials , some adults with pain caused by diabetic neuropathy nerve damage , as well as some adults with fibromyalgia, noticed improvement within 1 week of starting the drug. However, the National Alliance on Mental Illness notes that full improvement of depression symptoms may take up to 8 weeks. If you have questions about how Cymbalta works, or how long it takes to work, talk with your doctor or pharmacist.
Cymbalta can interact with several other medications. It can also interact with certain supplements. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Below are lists of medications that can interact with Cymbalta.
Before taking Cymbalta, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take.
Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Cymbalta can increase serotonin levels in your body. Using Cymbalta with other drugs that also increase serotonin may raise your risk for serotonin syndrome. Serotonin syndrome is a rare but potentially life threatening condition.
Taking multiple medications that increase serotonin levels could cause serotonin to build up to dangerous levels in your blood. Before taking Cymbalta, be sure to tell your doctor if you take any of the medications listed above. They may want to monitor you for any signs of serotonin syndrome. Or they may have you take a different drug to treat your condition.
Taking Cymbalta with these drugs may increase Cymbalta levels in your body. Slowing down this process could raise your risk for side effects from Cymbalta. Certain drugs have stronger effects on these enzymes. Examples of strong CYP1A2 inhibitors include:.
Examples of CYP2D6 inhibitors include:. Before you take Cymbalta, be sure to tell your doctor if you take any of these medications. They can determine which drug is the best fit for you.
Duloxetine is a type of antidepressant known as a serotonin-noradrenaline reuptake inhibitor SNRI. SNRIs are thought to work by increasing the amount of mood-enhancing chemicals serotonin and noradrenaline in the brain. You may see an improvement after 2 to 4 weeks. Improvements for nerve pain may take longer. Do not stop taking duloxetine after a week or two just because you feel it's not helping your symptoms.
Antidepressants like duloxetine help to gradually lift your mood so you feel better. You may notice that you sleep better and get on with people more easily because you're less anxious. Do not expect to feel better overnight, though. Some people feel worse during the first few weeks of treatment before they begin to feel better.
If you're taking it for nerve pain or urinary incontinence, you may also notice some of these feelings. For depression or anxiety - once you're feeling better, it's likely that you'll continue to take duloxetine for several more months. Most doctors recommend that you take antidepressants for 6 months to a year after you no longer feel depressed or anxious.
Stopping your medicine too soon can make depression and anxiety come back. For nerve pain or urinary incontinence - if duloxetine is helping your symptoms, you can continue taking it long term.
Your doctor may check that you're still having relief from the pain or urinary incontinence every few months. If you have been feeling better for 6 months or more, your doctor may suggest coming off duloxetine. Your doctor will probably recommend reducing your dose gradually over several weeks, or longer if you have been taking duloxetine for a long time. This is to help prevent any extra side effects you might get as a reaction to coming off the medicine. Do not stop taking duloxetine suddenly or without talking to your doctor first.
Taking antidepressants, including duloxetine, is just one of many ways to treat depression and anxiety. If duloxetine is not working for you, speak to your doctor - there may be other treatments you can try. If you start to have problems with your weight while taking duloxetine, talk to your doctor or pharmacist. During the first few days of taking duloxetine, it might be best to stop drinking alcohol until you see how the medicine affects you.
There's no firm evidence to suggest that taking duloxetine will reduce fertility in either men or women. But speak to a pharmacist or your doctor before taking it if you're trying to get pregnant. Speak to your doctor if you're planning to get pregnant while taking duloxetine. Duloxetine will not affect any type of contraception, including the combined pill or emergency contraception.
Some people cannot concentrate properly while they're taking duloxetine. When you first start taking duloxetine, it's a good idea to stop driving and cycling, and avoid using machines or tools, for the first few days until you know how this medicine makes you feel. Cannabis can affect the levels of duloxetine and make you more likely to get side effects. Talk to your doctor if you think you might use recreational drugs while taking duloxetine.
Page last reviewed: 31 January Next review due: 31 January Duloxetine On this page About duloxetine Key facts Who can and can't take it How and when to take it Side effects How to cope with side effects Pregnancy and breastfeeding Cautions with other medicines Common questions. About duloxetine Duloxetine is an antidepressant medicine.
Duloxetine comes as capsules and is only available on prescription. Multiple clinical trials show that Cymbalta can reduce fibromyalgia pain, both with and without comorbid depression. Studies also show that the drug continues to be effective for at least one year. Researchers don't understand exactly how this drug works.
However, a study Wang suggests that dampens spontaneous pain signals that result from nerve damage neuropathy. One theory of fibromyalgia pain is that it involves neuropathy in the small nerves near the surface of your skin. If that's true, it could be why Cymbalta is often effective against our pain. In that study, Cymbalta appeared to alleviate two pain types that are typical of fibromyalgia: hyperalgesia and allodynia.
The recommended Cymbalta dosage is 60 mg, taken once a day. It's generally started at 30 mg a day and then increased to 60 mg after about a week. Doses higher than this aren't believed to be more effective for fibromyalgia, and they are associated with a higher risk of side effects. People who want to stop taking this drug should talk to their healthcare provider about the proper way to gradually wean off of it; stopping suddenly is dangerous.
Your healthcare provider may also be able to help you lessen withdrawal symptoms. Cymbalta is associated with numerous possible side effects. Those that you should report to your healthcare provider right away include:.
Side effects of Cymbalta that don't usually require medical attention include:. If you're interested in trying Cymbalta, talk to your healthcare provider.
Be sure to carefully weigh the pros and cons and look into any possible negative interactions with other drugs you're taking. It's a good idea, with any medication, to have a list of possible side effects handy. You may want to let people close to you know about serious side effects, such as seizures, loss of contact with reality, or suicidal thoughts, so that they know what's happening, just in case.
It is important that your doctor knows all the other medications you use. Doctors are aware of the above list as well as other medications that commonly interact with Cymbalta. Only stop taking Cymbalta with doctor approval. Missing doses has the potential for increasing your risk of relapse in your symptoms. Stopping suddenly might result in withdrawal symptoms such as:.
Not only might they decrease the benefits that Cymbalta is delivering, but they could increase the severity of side effects. Also, alcohol consumption can increase the risk of liver problems while simultaneously taking Cymbalta. Also approved is Lyrica pregabalin , an epilepsy and nerve pain medication. Both physically and emotionally, fibromyalgia can be a difficult condition to live with. Medications such as Cymbalta have been effective in treating many of the symptoms of this chronic and often disabling disease.
If your doctor recommends Cymbalta, ask them questions about its ideal effects on treating your symptoms, as well as its potential side effects. Discuss your course of action if you experience side effects. Always make sure to give your doctor all information about other medications and supplements that you are taking. Fibromyalgia is a complex condition with a range of potential causes, treatments, and risk factors.
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